Fill a Collins glass with ice and set aside to chill.
Prepare a lime wedge for garnish.
Combine vodka, cranberry juice, and freshly squeezed pink grapefruit juice in a shaker with ice.
Shake briefly until well chilled, about 8–10 seconds.
Strain into the ice-filled Collins glass.
Garnish with the lime wedge and serve immediately.
Always use freshly squeezed pink grapefruit juice rather than bottled - the natural bitterness and brightness are what keep this simple three-ingredient build from tasting flat or overly sweet.
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